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The short answer
Start by defining the job the protector must do. Then compare coverage, surface textile, waterproof membrane, mattress depth and laundering instructions.
What to compare
Top-only, fitted five-sided and zippered six-sided designs serve different needs.
Separate the sleeping-surface fabric from any fill and the waterproof membrane.
Check supported mattress depth and the exact washing and drying instructions.
How to make the decision
Avoid treating a single marketing word—such as organic, cooling, natural or waterproof—as the whole decision. Check the construction and evidence behind the claim.
Continue with our protector selection guide or compare organic mattress protectors.